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Results for "

carboxylesterase inhibitor

" in MedChemExpress (MCE) Product Catalog:

16

Inhibitors & Agonists

4

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-142688
    Carboxylesterase-IN-2

    		Wnt Cancer
    Carboxylesterase-IN-2 (compound 4u) is a potent inhibitor of Carboxylesterase Notum with an IC50 less than or equal to 10 nM. Notum is a negative regulator of Wnt signaling acting through the hydrolysis of a palmitoleoylate ester, which is required for Wnt activity. Carboxylesterase-IN-2 has the potential for the research of cancer disease .
    Carboxylesterase-IN-2
  • HY-142689
    Carboxylesterase-IN-3

    		Wnt Cancer
    Carboxylesterase-IN-3 (compound 4y) is a potent inhibitor of Carboxylesterase Notum with an IC50 less than or equal to 10 nM. Notum is a negative regulator of Wnt signaling acting through the hydrolysis of a palmitoleoylate ester, which is required for Wnt activity. Carboxylesterase-IN-3 has the potential for the research of cancer disease .
    Carboxylesterase-IN-3
  • HY-144809
    Pancreatic lipase/Carboxylesterase 1-IN-1

    		Others Metabolic Disease
    Pancreatic lipase/Carboxylesterase 1-IN-1 (Compound 39) is a potent dual inhibitor of pancreatic lipase (PL) and human carboxylesterase 1A (hCES1A) with IC50 values of 2.13 µM and 0.055  µM against PL and hCES1A .
    Pancreatic lipase/Carboxylesterase 1-IN-1
  • HY-N10686
    Tanshinone IIA anhydride

    		Cholinesterase (ChE) Cancer
    Tanshinone IIA anhydride is a potent and irreversible human carboxylesterase (CE) inhibitor with Ki values of 1.9 nM and 1.4 nM for human CE1 and the human intestinal CE (hiCE), respectively .
    Tanshinone IIA anhydride
  • HY-141834
    Carboxylesterase-IN-1

    		Others Others
    Carboxylesterase-IN-1, a novel pesticide, exhibits inhibitory action on carboxylesterase at 50 μg/mL similar to the known inhibitor triphenyl phosphate.
    Carboxylesterase-IN-1
  • HY-106409
    Tefinostat
    1 Publications Verification

    CHR-2845

    		 HDAC Apoptosis Cancer
    Tefinostat (CHR-2845) is a monocyte/macrophage targeted histone deacetylase (HDAC) inhibitor. Tefinostat can be cleaved into active acid CHR-2847 by the intracellular esterase human carboxylesterase-1 (hCE-1). Tefinostat can be used for the research of leukaemias .
    Tefinostat
  • HY-147331
    Oseltamivir acid methyl ester

    		Antibiotic Neurological Disease
    Oseltamivir acid methyl ester is a precursor form of the neuraminidase inhibitor and antiviral oseltamivir acid. Oseltamivir acid methyl ester is converted to oseltamivir acid by carboxylesterase 1 (CES1) .
    Oseltamivir acid methyl ester
  • HY-N3474
    Isolicoflavonol

    		Others Others
    Isolicoflavonol potently inhibits hCES2A (Human carboxylesterase 2)-mediated fluorescein diacetate hydrolysis in a reversible and mixed inhibition manner, with Ki values less than 1.0 μM .
    Isolicoflavonol
  • HY-120602
    WWL229

    		Others Metabolic Disease
    WWL229 is a selective inhibitor of carboxylesterase 3 (Ces3) with an IC50 of 1.94 µM. WWL229 promotes lipid storage in cultured adipocytes and prevents basal lipolysis .
    WWL229
  • HY-B0418A
    Loperamide hydrochloride
    3 Publications Verification

    R-18553 hydrochloride

    		 Opioid Receptor Autophagy Neurological Disease Metabolic Disease Cancer
    Loperamide (hydrochloride) (R-18553 (hydrochloride)) is an opioid receptor agonist . Loperamide hydrochloride is a selective and competitive human intestinal carboxylesterases (hiCE) inhibitor. Loperamide hydrochloride has anti-diarrheal effect .
    Loperamide hydrochloride
  • HY-N3921
    Gancaonin I

    		Others Cancer
    Gancaonin I, an Isoflavone, exhibits moderate inhibition on human carboxylesterase 2 (hCES2A) with IC50 of 1.72 μM. Gancaonin I inhibits hCES2A-mediated fluorescein diacetate (FD) hydrolysis .
    Gancaonin I
  • HY-N1377
    Nevadensin

    		Bacterial Infection Metabolic Disease Inflammation/Immunology
    Nevadensin is a naturally occurring selective inhibitor of human carboxylesterase 1 (hCE1) with an IC50 of 2.64 μM. Nevadensin has a variety of pharmacological effects such as anti-mycobacterium tuberculosis activities, antitussive, anti-inflammatory and anti-hypertensive .
    Nevadensin
  • HY-N3413
    Kushenol X

    		Others Metabolic Disease
    Kushenol X, a flavonoid compound isolated from the roots of Sophora flavescens. Kushenol X is a potent β-glucuronidase and human carboxylesterase 2 (hCE2) inhibitor with IC50s of 2.07 μM and 3.05 μM, respectively .
    Kushenol X
  • HY-B0418AR
    Loperamide hydrochloride (Standard)

    R-18553 hydrochloride (Standard)

    		 Opioid Receptor Autophagy Neurological Disease Metabolic Disease Cancer
    Loperamide (hydrochloride) (Standard) is the analytical standard of Loperamide (hydrochloride). This product is intended for research and analytical applications. Loperamide (hydrochloride) (R-18553 (hydrochloride)) is an opioid receptor agonist . Loperamide hydrochloride is a selective and competitive human intestinal carboxylesterases (hiCE) inhibitor. Loperamide hydrochloride has anti-diarrheal effect .
    Loperamide hydrochloride (Standard)
  • HY-155228
    LK-44

    		Others Inflammation/Immunology
    hCES2A-IN-2 (Compound 44) is an orally active human carboxylesterase 2 (hCES2A) inhibitor (IC50: 5.02 μM). hCES2A-IN-2 improves Irinotecan (HY-16562)-induced delayed diarrhea .
    LK-44
  • HY-23148
    1-Methylisatin

    N-Methylisatin

    		 Others Others
    1-Methylisatin is a potent and selective CE (carboxylesterases) inhibitor, with Kis of 38.2 and 5.38 μM for hiCE and hCE1, respectively. 1-Methylisatin interacts with Hb (human adult hemoglobin) by hydrophobic binding and electrostatic attraction. 1-Methylisatin can be used in the study of regulation of agent metabolism in vivo .
    1-Methylisatin

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